By Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro
This authoritative quantity presents a holistic photograph of antibody-drug conjugates (ADCs). Fourteen finished chapters are divided into six sections together with an advent to ADCs, the ADC build, improvement concerns, panorama, IP and pharmacoeconomics, case experiences, and the way forward for the sphere. The booklet examines every thing from the choice of the antibody, the drug, and the linker to a dialogue of developmental concerns reminiscent of formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory demanding situations. It additionally explores pharmacoecomonics and highbrow homes, together with lately issued patents and the fee research of drug remedy. Case reviews are offered for the 3 ADCs that experience bought FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), in addition to an ADC in late-stage scientific trials, glembatumumab vedotin (CDX-011). ultimately, the quantity offers a standpoint by means of the editors at the destiny instructions of ADC improvement and scientific functions. Antibody-Drug Conjugates is a realistic and systematic source for scientists, professors, and scholars attracted to increasing their wisdom of state-of-the-art examine during this interesting field.
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Extra resources for Antibody-Drug Conjugates: The 21st Century Magic Bullets for Cancer (AAPS Advances in the Pharmaceutical Sciences Series)
Antibody-Drug Conjugates: The 21st Century Magic Bullets for Cancer (AAPS Advances in the Pharmaceutical Sciences Series) by Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro